Endometrial dating infertility
In this study, we tried to investigate the clinical effects of p FET in unexplained RIF patients according to the use of classic histologic endometrial dating to estimate the timing of the window of implantation and to adjust embryo transfer time in natural cycle.
Subjects in this group will be treated with personalized frozen-thawed embryo transfer.
The pars functionalis is known as the decidua during pregnancy, when it underlies the placenta. The mucous membrane forming the inner layer of the uterine wall; it consists of a simple columnar epithelium and a lamina propria that contains simple tubular uterine glands.
the lining of the uterus in female mammals, being a glandular MUCUS membrane that undergoes changes during the OESTRUS CYCLE during which it builds up under the influence of OESTROGEN in preparation for receiving the fertilized egg.
Where fertilization does not occur, it regresses, or in the case of humans, anthropoid apes and Old-World monkeys, it breaks down over a few days, producing bleeding. Expression and regulation of prostaglandin transporters, ATP-binding cassette, subfamily C, member 1 and 9, and solute carrier organic anion transporter family, member 2A1 and 5A1 in the uterine endometrium during the estrous cycle and pregnancy in pigs cancer, and it is widely considered to develop from endometrial intraepithelial carcinoma, which is related to malignant transformation of the endometrial surface epithelium (such as a benign endometrial polyp).
is the best accessible tissue for histopathological evaluation of uterine bleeding, several methods are used for endometrial sampling among which the dilatation of the cervix and curettage of the uterine cavity under general anaesthesia has long been the gold standard for the assessment of AUB.
CONCLUSION(S): Histological dating of the endometrium does not discriminate between women of fertile and infertile couples and should not be used in the routine evaluation of infertility.The utility of histological dating of endometrium in the evaluation of infertile couples is uncertain.DESIGN: Prospective multicenter study, with subjects randomly assigned to biopsy timing.Criterion standard for infertility was 12 months of unprotected, regular intercourse without conception and for fertility at least one live birth within 2 years. PATIENT(S): Volunteer subjects (847) recruited at 12 clinical sites participating in the National Institutes of Health-funded Reproductive Medicine Network.Inclusion criteria included ages 20-39 years, regular menstrual cycles, and no hormonal treatment or contraceptive use for 1 month before the study.
After detection of the LH surge, subjects were randomized to biopsy in the mid (days 21-22) or the late (days 26-27) luteal phase.